Abstract Search

ea0029p507 | Diabetes | ICEECE2012

QRFP43 and its fragment 26RFa both promote β-cell survival but differently regulate insulin secretion and glucose uptake in pancreatic β-cells and human pancreatic islets

Trovato L. , Settanni F. , Gallo D. , Gargantini E. , Bergandi L. , Ong H. , Ghigo E. , Granata R.

RFamides are a family of peptides containing arginine-phenylalanine-amide at their C terminus. A novel 43-amino acid RFamide, named QRFP43, and a shorter endogenous peptide 26RFa, were discovered and identified as ligands of the G protein-coupled receptor GPR103. Different studies have shown that RFamides, such as neuropeptide FF and QRFP43 and 26RFa, play a role in food intake, thermogenesis and energy homeostasis. Here, we investigated the effects of QRFP peptides on surviva...

0 shares

Endocrine Abstracts

QRFP43 and its fragment 26RFa both promote β-cell survival but differently regulate insulin secretion and glucose uptake in pancreatic β-cells and human pancreatic islets

BiosciAbstracts